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Total results with these characteristics: 82

Disease: Shigellosis and enterotoxigenic Escherichia coli (ETEC)

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Development of a Low-Dose Challenge Model for Evaluation of Vaccines for Enterotoxigenic E. coli (ETEC) in Volunteers

This presentation from the Vaccines for Enteric Diseases conference provides results from a clinical trial that found the human challenge model currently being used to test vaccines against enterotoxigenic Escherichia coli (ETEC) is utilizing a …

Author: Harro C, DeNearing B, Marcum A, et al.

Publication date: 2009

Diarrheal Disease: Solutions to Defeat a Global Killer

Diarrheal Disease: Solutions to Defeat a Global Killer presents scientific evidence to support strategies to scale up use of interventions, including safe water, improved sanitation and hygiene, breastfeeding and optimal complementary feeding, …

Author: PATH

Publication date: 2009

Diarrhoea: Why Children Are Still Dying and What Can Be Done

This joint report from the World Health Organization and the United Nations Children's Fund (UNICEF) focuses attention on the prevention and management of diarrheal diseases. It examines the latest available information on the burden of childhood …

Author: World Health Organization, United Nations Children's Fund

Publication date: 2009

Disease Burden Due to Enterotoxigenic Escherichia coli (ETEC) in the First Two Years of Life in an Urban Community in Bangladesh

Published in Infection and Immunity, a cohort of 321 children were followed from birth up to two years to determine the incidence of enterotoxigenic Escherichia coli (ETEC) in Bangladesh. Children with ETEC diarrhea were underweight and stunted …

Author: Qadri F, Saha A, Ahmed T

Publication date: 2007

Disease Control Priorities, Third Edition: Volume 2. Reproductive, Maternal, Newborn, and Child Health

This book focuses on maternal conditions, childhood illness, and malnutrition. Specifically, the chapters address acute illness and undernutrition in children, principally under age five. Of particular interest may be chapters 9, 10, and 19, which …

Author: Black RE, Laxminarayan R, Temmerman M, Walker N, eds.

Publication date: 2016

The Economic Impact of Childhood Acute Gastroenteritis on Malawian Families and the Healthcare System

This article, published in BMJ Open, reports on a study that found significant financial burden from childhood diarrheal disease to the healthcare system and to households in Malawi. The latter face the risk of consequent impoverishment, as the …

Author: Hendrix N, Bar-Zeev N, Atherly D, et al.

Publication date: 2017

Enteric Infections, Diarrhea, and Their Impact on Function and Development

Enteric infections, with or without overt diarrhea, have profound effects on intestinal absorption, nutrition, and childhood development as well as on global mortality. Oral rehydration therapy has reduced the number of deaths from dehydration …

Author: Petri Jr. WA, Miller M, Binder HJ, et al.

Publication date: 2008

Enterotoxigenic Escherichia coli (ETEC)

This web page provides information on ETEC, its transmission, prevention of the disease, and more.

Author: US Centers for Disease Control and Prevention

Escherichia coli Infections

This web page provides general information on Escherichia coli bacteria and symptoms of disease. It also includes links to other World Health Organization web pages related to E. coli.

Author: World Health Organization

Estimating Diarrheal Illness and Deaths Attributable to Shigellae and Enterotoxigenic Escherichia coli Among Older Children, Adolescents, and Adults in South Asia and Africa

This article, published in PLOS Neglected Tropical Diseases, aims to quantify the overall burden of shigellosis and enterotoxigenic Escherichia coli (ETEC) diarrhea among older children, adolescents, and adults in Africa and South Asia, the two …

Author: Lamberti LM, Bourgeois AL, Fischer Walker CL, Black RE, Sack D

Publication date: 2014

Evaluation of the Safety, Tolerability, and Immunogenicity of an Oral, Inactivated Whole-Cell Shigella flexneri 2a Vaccine in Healthy Adult Subjects

This article, published in Clinical and Vaccine Immunology, reports the results of a Phase 1 clinical study that evaluated the safety and immunogenicity of a Shigella vaccine candidate. The results showed that the vaccine was well tolerated and …

Author: Chakraborty S, Harro C, DeNearing B, et al.

Publication date: 2016

Evaluation of Vaccines Against Enteric Infections: A Clinical and Public Health Research Agenda for Developing Countries

This article, from the Philosophical Transactions of the Royal Society B, provides a review of the enteric vaccines currently available and their lack of use in developing countries. The author purports that the reasons for this are multiple and …

Author: Clemens J

Publication date: 2011

Global Burden of Disease

The Global Burden of Disease Study is the most comprehensive global observational epidemiological study to date. It describes mortality and morbidity from major diseases, injuries, and risk factors to health at the global, national, and regional …

Author: Global Burden of Disease Study Collaborators

High Disease Burden of Diarrhea Due to Enterotoxigenic Escherichia coli Among Rural Egyptian Infants and Young Children

Published in the Journal of Clinical Microbiology, this article examines the burden of diarrheal disease due to enterotoxigenic E. coli among rural Egyptian infants and young children, which has an incidence of 1.5 episodes per child per year and …

Author: Rao M, Abu-Elyazeed R, Savarino S, et al.

Publication date: 2003

Immune Responses and Protection in Children in Developing Countries Induced by Oral Vaccines

Oral mucosal vaccines have great promise for generating protective immunity against intestinal infections for the benefit of large numbers of people especially young children. However, these vaccines are not equally immunogenic nor protective in …

Author: Qadri F, Bhuiyan TR, Sack DA, Svennerholm A-M

Publication date: 2013

Inactivated and Subunit Vaccines to Prevent Shigellosis

This article, published in Expert Review of Vaccines, describes how vaccines to prevent shigellosis can be divided into living and nonliving approaches. Several nonliving Shigella vaccines are currently at different stages of development and show …

Author: Kaminski RW, Oaks EV

Publication date: 2009

Individual-Specific Changes in the Human Gut Microbiota After Challenge With Enterotoxigenic Escherichia coli and Subsequent Ciprofloxacin Treatment

This article, published in BMC Genomics, reports the results of a study that aimed to understand the impact of the human intestinal microbiota on the initiation and progression of enterotoxigenic Escherichia coli (ETEC) diarrhea. The authors found …

Author: Pop M, Paulson JN, Chakraborty S, et al.

Publication date: 2016

Innovation in Enteric Vaccine Development: Addressing Bacterial Causes of Diarrhea

This fact sheet describes PATH's enteric vaccine project from a technical perspective. It includes an overview of PATH's vaccine development portfolio, research activities, and partners to support the development of effective and affordable vaccines …

Author: PATH

Publication date: 2016

An Integrated Approach to Confronting Diarrheal Disease

This briefing paper provides an overview of the tools and interventions involved with an integrated approach to diarrheal disease control, including vaccines, oral rehydration therapy, breastfeeding, and zinc treatment. The document also advocates …

Author: PATH

Publication date: 2011

Integrating Diarrheal Disease and Pneumonia Control

This fact sheet describes PATH's integrated approach to tackling diarrheal disease and pneumonia, two of the leading killers of young children. This approach emphasizes overlapping protection, the scale-up of proven methods, and the development of …

Author: PATH

Publication date: 2013

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