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Total results with these characteristics: 83

Disease: Shigellosis and enterotoxigenic Escherichia coli (ETEC)

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Intradermal Delivery of Vaccines: A Review of the Literature and the Potential for Development for Use in Low- and Middle-Income Countries

The purpose of this report is: (1) to summarize the clinical evidence supporting the intradermal route for vaccine administration and the devices being developed for this purpose; (2) to determine whether intradermal delivery broadly holds promise …

Author: PATH

Publication date: 2009

Introducing New Vaccines Into Developing Countries: Obstacles, Opportunities, and Complexities

This commentary, published in Nature Medicine, reviews current trends that may affect whether the most promising of the 350 vaccine candidates under development will eventually be used in programs for the poor in developing countries. It also …

Author: Clemens J, Jodar L

Publication date: 2005

Landscape Analysis: Trends in Vaccine Availability and Novel Vaccine Delivery Technologies: 2008–2025

This landscape analysis identifies trends in the availability of vaccines and novel vaccine delivery technologies that are and will be of relevance to low- and middle-income countries from the present through 2025.

Author: PATH, World Health Organization

Publication date: 2008

Live-Attenuated Shigella Vaccines

This article, published in Expert Review of Vaccines, describes several live attenuated Shigella vaccines, with well-defined mutations in specific genes, that have shown great promise in eliciting significant immune responses when given orally to …

Author: Venkatesan MM, Ranallo RT

Publication date: 2006

Magnitude and Impact of Diarrheal Diseases

Published in The Archives of Medical Research, this article reviews the high costs of diseases of poverty, increasing diarrhea morbidity (despite decreasing mortality), and new emerging evidence for long-term consequences of early childhood …

Author: Guerrant RL, Kosek M, Moore S, et al.

Publication date: 2002

Monitoring Visualization Tool for the Global Action Plan for Pneumonia and Diarrhoea (GAPPD)

This data visualization tool enables users to monitor progress against GAPPD targets for 2025/2030/2040, as well as the progress made by 136 low- and middle-income countries in averting childhood diarrhea and pneumonia deaths. The data are also …

Author: World Health Organization

Monoclonal Antibodies to Shigella LPS Useful for Vaccine Production

This article, published in Clinical and Vaccine Immunology, reports the results of a study that produced monoclonal antibodies against serotype-specific Shigella lipopolysaccharides (LPS). These Shigella LPS-specific monoclonal antibodies may be …

Author: Lin J, Smith MA, Benjamin Jr. WH, Kaminski RW, Wenzel H, Nahm MH

Publication date: 2016

Moving the Needle

This quarterly e-newsletter provides updates from PATH’s Center for Vaccine Innovation and Access on its vaccine development efforts, as well as related supporting work, such as developing human challenge models, building capacity of …

Author: PATH

A Multicenter Study of Shigella Diarrhea in Six Asian Countries: Disease Burden, Clinical Manifestations, and Microbiology

Published in PLoS Medicine, this article discusses a prospective, population-based study in six Asian countries to gain a better understanding of the current disease burden, clinical manifestations, and microbiology of shigellosis in Asia.

Author: von Seidlein L, Kim DR, Ali M, et al.

Publication date: 2006

New Vaccines Against Enteric Bacteria for Children in Less Developed Countries

This article, published in Expert Review of Vaccines, describes how the development of safe and effective multicomponent, whole-bacterial cell vaccine(s) against enterotoxigenic Escherichia coli and Shigella, two important pathogens for which no …

Author: Walker RI

Publication date: 2005

The Oral, Live Attenuated Enterotoxigenic Escherichia coli Vaccine ACE527 Reduces the Incidence and Severity of Diarrhea in a Human Challenge Model of Diarrheal Disease

This article, published in Clinical and Vaccine Immunology, presents findings from a Phase 2b challenge study of an oral, live attenuated, three-strain recombinant bacterial vaccine, ACE527, against enterotoxigenic Escherichia coli (ETEC). Fifty-six …

Author: Darsley MJ, Chakraborty S, DeNearing B, et al.

Publication date: 2012

Persisting Consequences of Intestinal Infection

This issue of the Old Herborn University Seminar Monograph provides a summary of the discussions at an expert workshop hosted by the Old Herborn University Foundation in June 2013. The discussions were held to assess the experts' epidemiological and …

Author: Heidt PJ, Lange D, Riddle MS, Walker RI, Rusch V, eds.

Publication date: 2014

Pneumonia and Diarrhoea: Tackling the Deadliest Diseases for the World’s Poorest Children

This report focuses on the huge potential to narrow the child survival gap between the richest and the poorest by focusing on pneumonia and diarrhea—the two primary killers of children under the age of five. It includes a review of the current …

Author: United Nations Children's Fund

Publication date: 2012

Policymakers Views Regarding the Introduction of New-Generation Vaccines Against Typhoid Fever, Shigellosis, and Cholera in Asia

Published in Vaccine, this article disusses face-to-face interviews and meetings with more than 160 policymakers and other influential professionals in seven large Asian countries (Bangladesh, China, India, Indonesia, Pakistan, Thailand and …

Author: DeRoeck D, Clemens JD, Nyamete A, Mahoney RT

Publication date: 2005

Presentation Matters: Buffers, Packaging, and Delivery Devices for New, Oral Enteric Vaccines for Infants

This article, published in Human Vaccines & Immunotherapeutics, highlights the importance of final vaccine presentation features in achieving optimal vaccine impact for new oral enteric vaccine candidates. Oral administration of vaccines …

Author: Lal M, Jarrahian C

Publication date: 2017

Progress and Hurdles in the Development of Vaccines Against Enterotoxigenic Escherichia coli in Humans

This article, published in the Expert Review of Vaccines, describes the status of vaccines under development to address enterotoxigenic Escherichia coli (ETEC), which have been designed to stimulate local intestinal immunity and are delivered either …

Author: Zhang W, Sack DA

Publication date: 2012

Protecting Aluminum-Adjuvanted Vaccines From Freeze Damage

This fact sheet describes how PATH developed a low-cost and straightforward technology for protecting aluminum-adjuvanted liquid vaccines from the irreversible damage that results from freezing. Many current vaccines of importance to global health …

Author: PATH

Publication date: 2012

Protecting Children From Diarrheal Disease: PATH Takes a Comprehensive Approach to Combating This Leading Cause of Child Deaths

This fact sheet provides an overview of PATH's work, including vaccine development and introduction, in protecting children from diarrheal disease.

Author: PATH

Publication date: 2015

PubMed Searches: ETEC and Shigella

These pre-formatted PubMed searches will retrieve journal citations and available abstracts that address relevant issues related to ETEC and Shigella. Documents may be ordered through Loansome Doc if you have established an agreement with a …

Author: Various

Quantitative PCR for Detection of Shigella Improves Ascertainment of Shigella Burden in Children With Moderate-to-Severe Diarrhea in Low-Income Countries

This article, published in the Journal of Clinical Microbiology, reports on a study to estimate the prevalence of Shigella by using a new quantitative PCR (qPCR) assay to detect the bacteria in the stool samples of 3,533 children aged less than 59 …

Author: Lindsay B, Ochieng JB, Ikumapayi UN, et al.

Publication date: 2013

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