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Total results with these characteristics: 83

Disease: Shigellosis and enterotoxigenic Escherichia coli (ETEC)

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R&D for Diarrhoeal Diseases

While preventive measures such as clean drinking water and sanitation can reduce the risk of infection from diarrheal diseases, research and development (R&D) of new tools is equally important, particularly for vaccines as they can prevent …

Author: Policy Cures

Publication date: 2013

Reaching a Consensus on Management Practices and Vaccine Development Targets for Mitigation of Infectious Diarrhoea Among Deployed US Military Forces

Published in the Journal of Evalution in Clinical Practice, this study was part of a research effort to identify and quantify factors related to the cost-effectiveness of a vaccine acquisition strategy to reduce the burden of infectious diarrhea on …

Author: Riddle MS, Tribble DR

Publication date: 2008

Reactive Arthritis Following Culture-Confirmed Infections with Bacterial Enteric Pathogens in Minnesota and Oregon: A Population-based Study

This article, published in Annals of the Rheumatic Diseases, describes the epidemiology and clinical spectrum of reactive arthritis (ReA) following culture-confirmed infection with bacterial enteric pathogens in a population-based study in the …

Author: Townes JM, Deodhar AA, Laine ES, et al.

Publication date: 2008

Recent Progress Towards Development of a Shigella Vaccine

The burden of dysentery due to shigellosis among children in the developing world is a major concern, but no licensed vaccine is available. This review article, published in Expert Review of Vaccines, provides an update on Shigella vaccine …

Author: Camacho AI, Irache JM, Gamazo C

Publication date: 2013

Recommendations Regarding the Development of Combined Enterotoxigenic Eschericha coli and Shigella Vaccines for Infants

This article, published in Vaccine, reports on a workshop hosted by PATH in October 2013 to solicit expert opinions on the potential merits and challenges of developing combined enterotoxigenic Escherichia coli and Shigella vaccine products to …

Author: Walker RI, Clifford A

Publication date: 2015

Refinement of a Human Challenge Model for Evaluation of Enterotoxigenic Escherichia coli Vaccines

This article, published in Clinical and Vaccine Immunology, reports on a study which found that a lower dose than used previously of the human challenge model for enterotoxigenic Escherichia coli diarrhea using strain H10407 is sufficient for …

Author: Harro C, Chakraborty S, Feller A, et al.

Publication date: 2011

Safety and Immunogenicity of a Single Oral Dose of Recombinant Double-Mutant Heat-Labile Toxin (dmLT) Derived from Enterotoxigenic Escherichia coli (ETEC)

This article, published in Clinical and Vaccine Immunology, reports on a Phase 1 clinical trial which determined the safety and immunogenicity of a recombinantly produced dmLT of ETEC. Study results showed that a single oral dose of dmLT was well …

Author: El-Kamary SS, Cohen MB, Bourgeois AL, et al.

Publication date: 2013

Safety and Immunogenicity of an Improved Oral Inactivated Multivalent Enterotoxigenic Escherichia coli (ETEC) Vaccine Administered Alone and Together with dmLT Adjuvant in a Double-Blind, Randomized, Placebo-Controlled Phase I Study

This article, published in Vaccine, reports on the results of a Phase 1 study of an oral vaccine candidate against enterotoxigenic Escherichia coli (ETEC) administered in combination with a novel mucosal adjuvant, the double-mutant heat-labile toxin …

Author: Lundgren A, Bourgeois L, Carlin N, et al.

Publication date: 2014

Shigella Isolates From the Global Enteric Multicenter Study Inform Vaccine Development

This article, published in Clinical Infectious Diseases, reports on the Shigella serotypes identified in the Global Enteric Multicenter Study conducted in Africa and Asia in order to guide vaccine development efforts. The authors found that Shigella …

Author: Livio S, Strockbine NA, Panchalingam S, et al.

Publication date: 2014

A Shigella Vaccine Against Prevalent Serotypes

This article, published in Clinical Infectious Diseases, discusses the case for development of a pediatric vaccine against Shigella, which is a leading cause of diarrheal disease among children aged 12 to 59 months. The authors provide an analysis …

Author: Van de Verg LL, Venkatesan MM

Publication date: 2014

Status of Vaccine Research and Development for Enterotoxigenic Escherichia coli

This article, published in Vaccine, provides an overview of enterotoxigenic Escherichia coli (ETEC) disease and outlines current efforts in vaccine development. It includes general approaches to vaccine development for low- and middle-income …

Author: Bourgeois AL, Wierzba TF, Walker RI

Publication date: 2016

Status of Vaccine Research and Development for Shigella

This article, published in Vaccine, provides a Shigella vaccine landscape assessment. It includes an overview of Shigella disease and outlines general approaches to vaccine development for low- and middle-income markets, the status of Shigella …

Author: Mani S, Wierzba T, Walker RI

Publication date: 2016

Stop the Cycle of Diarrheal Disease: A State of the Field Report

This report discusses current progress in reducing deaths due to diarrhea and illustrates strategies to scale up the use of existing interventions, including safe water, improved sanitation and hygiene, breastfeeding and optimal complementary …

Author: PATH

Publication date: 2017


This website details the work of STOPENTERICS, a consortium of independent organizations around the world dedicated to accelerating the development of Shigella and enterotoxigenic Escherichia coli vaccines for children in the developing world.


A Study of Different Buffers to Maximize Viability of an Oral Shigella Vaccine

Live, oral vaccines against bacterial causes of diarrhea have to be formulated and administered in a way that protects them from the harsh acidic gastric environment. However, little work has been done to evaluate the volume of buffer needed to …

Author: Chandrasekaran L, Lal M, Van De Verg LL, Venkatesan MM

Publication date: 2015

Summary of Vaccine Stability Data

These documents provide stability data as of November 2012 on commonly used, licensed vaccines and stability data as of May 2012 from available data on novel, investigational vaccine formulations. Data are sorted by vaccine in a table format in both …

Author: PATH, Working in Tandem Ltd.

Publication date: 2012

Toxins and Virulence Factors of Enterotoxigenic Escherichia coli Associated With Strains Isolated From Indigenous Children and International Visitors to a Rural Community in Guatemala

This article, published in Epidemiology and Infection, reports on a study comparing the frequency, enterotoxin, and colonization factor (CF) profiles of enterotoxigenic Escherichia coli (ETEC) strains among children living in a rural community in …

Author: Torres OR, Gonzalez W, Lemus O, et al.

Publication date: 2014

Tracking the New Vaccine Pipeline

This web page links to a spreadsheet that tracks the global clinical vaccine development plans for seven pathogen areas including malaria, respiratory syncytial virus, enterotoxigenic Escherichia coli, and Shigella. For each disease area, candidate …

Author: World Health Organization

US Department of Defense and PATH: Working Together to Advance Global Health Innovations

This fact sheet describes the partnership between PATH and the US Department of Defense (DoD). It highlights PATH projects—including the development of vaccines against enterotoxigenic Escherichia coli, Shigella, and malaria, along with work on …

Author: PATH

Publication date: 2016

Use of Quantitative Molecular Diagnostic Methods to Identify Causes of Diarrhoea in Children: A Reanalysis of the GEMS Case-Control Study

This article, published in The Lancet, reports the results of a study that reanalyzed the Global Enteric Multicenter Study data to identify the leading causes of diarrhea in children under five years of age in sub-Saharan Africa and south Asia. The …

Author: Liu J, Platts-Mills JA, Juma J, et al.

Publication date: 2016

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