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Total results with these characteristics: 91

Disease: Malaria

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Development of a Transmission-Blocking Malaria Vaccine: Progress, Challenges, and the Path Forward

This article, published in Vaccine, describes the progress made since 2010 in critical areas of developing transmission-blocking malaria vaccines. It also highlights key challenges that remain and outlines important next steps to maximize the …

Author: Nunes JK, Woods C, Carter T, et al.

Publication date: 2014

Disease Control Priorities, Third Edition: Volume 2. Reproductive, Maternal, Newborn, and Child Health

This book focuses on maternal conditions, childhood illness, and malnutrition. Specifically, the chapters address acute illness and undernutrition in children, principally under age five. Of particular interest may be chapters 9, 10, and 19, which …

Author: Black RE, Laxminarayan R, Temmerman M, Walker N, eds.

Publication date: 2016

Efficacy and Safety of RTS,S/AS01 Malaria Vaccine With or Without a Booster Dose in Infants and Children in Africa: Final Results of a Phase 3, Individually Randomized, Controlled Trial

This article, published in The Lancet, reports the results of a study on the efficacy and safety of the RTS,S/AS01 candidate malaria vaccine. The authors conclude that RTS,S/AS01 prevented a substantial number of cases of clinical malaria over a …

Author: RTS,S Clinical Trials Partnership

Publication date: 2015

Efficacy and Safety of the RTS,S/AS01 Malaria Vaccine During 18 Months After Vaccination: A Phase 3 Randomized, Controlled Trial in Children and Young Infants at 11 African Sites

This article, published in PLoS Medicine, reports on follow-up data from a Phase 3 trial conducted to test the effectiveness of the malaria vaccine candidate RTS,S/AS01 in children and young infants. RTS,S/AS01 prevented many cases of clinical and …

Author: RTS,S Clinical Trials Partnership

Publication date: 2014

Efficacy of RTS,S/AS01E Vaccine Against Malaria in Children 5 to 17 Months of Age

This study, published in the New England Journal of Medicine, evaluated the efficacy of the RTS,S malaria vaccine given with a more immunogenic adjuvant system (AS01E) than one used in a previous study (AS02A). The study was conducted in …

Author: Bejon P, Lusingu J, Olotu A, et al.

Publication date: 2008

Estimating the Full Public Health Value of Vaccination

This conference report, published in Vaccine, builds upon a discussion in the public health community on how to assess and incorporate, in addition to safety and measures of protective efficacy, the full public health value (FPHV) of preventive …

Author: Gessner BD, Kaslow D, Louis J, et al.

Publication date: 2017

Factors Likely to Affect Community Acceptance of a Malaria Vaccine in Two Districts of Ghana: A Qualitative Study

This article, published in PLoS ONE, reports on a study that explored community-level factors that could affect future vaccine acceptance in Ghana once a malaria vaccine is recommended for introduction and use. It also provides recommendations for a …

Author: Meñaca A, Tagbor H, Adjei R, et al.

Publication date: 2014

Fighting Malaria Today and Tomorrow

This fact sheet describes PATH's work in malaria control and prevention, including its work under the Malaria Control and Evaluation Partnership in Africa and the PATH Malaria Vaccine Initiative.

Author: PATH

Publication date: 2016

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

A malaria vaccine, deployed in combination with current malaria-control tools, could play an important role in future control and eventual elimination of malaria in Africa. This article, published in the New England Journal of Medicine, reports the …

Author: The RTS,S Clinical Trials Partnership

Publication date: 2011

Fractional Third and Fourth Dose of RTS,S/AS01 Malaria Candidate Vaccine: A Phase 2a Controlled Human Malaria Parasite Infection and Immunogenicity Study

This article, published in The Journal of Infectious Diseases, describes how immunization regimens, including a delayed fractional third dose, were assessed for potential increased protection against malaria and immunologic responses. The authors …

Author: Regules JA, Cicatelli SB, Bennett JW, et al.

Publication date: 2016

From Pipeline to Product: Malaria R&D Funding Needs Into the Next Decade

This report serves as a tool to guide policymakers’ investment in new tools to control malaria, contain emerging threats, and move toward the goal of eradicating malaria from the world. It looks at the estimated funding needed for Research & …

Author: PATH

Publication date: 2013

Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine

This article, published in The New England Journal of Medicine, reports on an analysis of samples from an efficacy study of the RTS,S/AS01 malaria vaccine to determine whether the vaccine efficacy was specific to certain parasite genotypes at the …

Author: Neafsey DE, Juraska M, Bedford T, et al.

Publication date: 2015

Global Burden of Disease

The Global Burden of Disease Study is the most comprehensive global observational epidemiological study to date. It describes mortality and morbidity from major diseases, injuries, and risk factors to health at the global, national, and regional …

Author: Global Burden of Disease Study Collaborators

A Hopeful Beginning for Malaria Vaccines

This editorial, published in the New England Journal of Medicine, discusses the RTS,S vaccine against malaria and the significance of this being the first malaria vaccine to reach an advanced stage of development.

Author: Collins WE, Barnwell JW

Publication date: 2008

Immunization Matters

This quarterly e-newsletter provides updates from PATH’s Center for Vaccine Innovation and Access on late-stage and licensed vaccines included in its portfolio as well as its work on health economics and optimization, operations research, and …

Author: PATH

Impact of Placental Malaria and Hypergammaglobulinemia on Transplacental Transfer of Respiratory Syncytial Virus Antibody in Papua New Guinea

As maternal immunization becomes an increasingly important strategy for protection of very young infants, identification of factors that could impact vaccine effectiveness by modifying the efficiency of transplacental antibody transport will be …

Author: Atwell JE, Thumar B, Robinson LJ, et al.

Publication date: 2016

An Inter-Laboratory Comparison of Standard Membrane-Feeding Assays for Evaluation of Malaria Transmission-Blocking Vaccines

This article, published in the Malaria Journal, examined the variability of the standard membrane-feeding assay (SMFA)—the “gold standard” assay to measure transmission-blocking activities of Plasmodium falciparum infection—across different …

Author: Miura K, Stone WJR, Koolen KM, et al.

Publication date: 2016

Introducing New Vaccines Into Developing Countries: Obstacles, Opportunities, and Complexities

This commentary, published in Nature Medicine, reviews current trends that may affect whether the most promising of the 350 vaccine candidates under development will eventually be used in programs for the poor in developing countries. It also …

Author: Clemens J, Jodar L

Publication date: 2005

Jordan Report: Accelerated Development of Vaccines 2012

This comprehensive report includes expert articles on a variety of vaccine-related topics and updates on vaccine research for specific infectious diseases, such as influenza, malaria, respiratory syncytial virus, and rotavirus.

Author: US National Institute of Allergy and Infectious Diseases

Publication date: 2012

Landscape Analysis: Trends in Vaccine Availability and Novel Vaccine Delivery Technologies: 2008–2025

This landscape analysis identifies trends in the availability of vaccines and novel vaccine delivery technologies that are and will be of relevance to low- and middle-income countries from the present through 2025.

Author: PATH, World Health Organization

Publication date: 2008

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