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Disease: Rotavirus

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Effectiveness of Pentavalent and Monovalent Rotavirus Vaccines in Concurrent Use Among US Children <5 Years of Age, 2009–2011

This article, published in Clinical Infectious Diseases, summarizes a study that assessed vaccine effectiveness of RotaTeq (RV5; 3 doses) and Rotarix (RV1; 2 doses) at reducing rotavirus acute gastroenteritis inpatient and emergency department (ED) …

Author: Payne DC, Boom JA, Staat MA, et al.

Publication date: 2013

Effectiveness of Rotavirus Vaccine Against Hospital Admission for Rotavirus Diarrhoea in Brazilian Children: A Case-Control Study

This meeting abstract, published in The Lancet, shares the results of a study on the effectiveness of rotavirus vaccine to prevent rotavirus hospitalizations among infants in Brazil. The authors found that two doses of the vaccine were highly …

Author: Ichihara MYT, Rodrigues LC, Santos CAST, et al.

Publication date: 2014

Efficacy of a Low-Cost, Heat-Stable Oral Rotavirus Vaccine in Niger

This article, published in the New England Journal of Medicine, reports the results of a Phase 3 trial to assess the efficacy and safety of a heat-stable, live, oral bovine rotavirus pentavalent vaccine (BRV-PV) against severe rotavirus …

Author: Isanaka S, Guindo O, Langendorf C, et al.

Publication date: 2017

Efficacy of a Monovalent Human-Bovine (116E) Rotavirus Vaccine in Indian Infants: A Randomised, Double-Blind, Placebo-Controlled Trial

This article, published in The Lancet, reports on the results of a Phase 3 study to assess the efficacy and tolerability of a monovalent human-bovine rotavirus vaccine (116E) for severe rotavirus gastroenteritis in low-resource urban and rural …

Author: Bhandari N, Rongsen-Chandola T, Bavdekar A, et al.

Publication date: 2014

Efficacy of Human Rotavirus Vaccine Against Rotavirus Gastroenteritis During the First 2 Years of Life in European Infants: Randomised, Double-Blind Controlled Study

This article, published in The Lancet, presents data that show high efficacy for GSK's Rotarix® administered with routine vaccines. Over two seasons, Rotarix® demonstrated 90 percent efficacy against severe rotavirus among European children and …

Author: Vesikari T, Karvonen A, Prymula R, et al.

Publication date: 2007

Efficacy of Pentavalent Rotavirus Vaccine Against Severe Rotavirus Gastroenteritis in Infants in Developing Countries in Asia: A Randomised, Double-Blind, Placebo-Controlled Trial

This article, published in The Lancet, assesses the clinical efficacy of the pentavalent, live oral rotavirus vaccine for the prevention of severe rotavirus gastroenteritis in infants in Bangladesh and Vietnam. Study results demonstrated vaccine …

Author: Zaman K, Dang DA, Victor JC, et al.

Publication date: 2010

Efficacy of Pentavalent Rotavirus Vaccine Against Severe Rotavirus Gastroenteritis in Infants in Developing Countries in Sub-Saharan Africa: A Randomised, Double-Blind, Placebo-Controlled Trial

This article, published in The Lancet, shares results of an efficacy study of the pentavalent, live oral rotavirus vaccine in Ghana, Kenya, and Mali. Results showed 39.3 percent efficacy against  severe rotavirus gastroenteritis. The authors …

Author: Armah GE, Sow SO, Breiman RF, et al.

Publication date: 2010

Efficacy of the Human Rotavirus Vaccine RIX4414 in Malnourished Children

This study, published in the Journal of Infectious Diseases, determined that the Rotarix® vaccine produced by GlaxoSmithKline decreased the incidence severe gastroenteritis caused by rotavirus at comparable rates among well-nourished and …

Author: Perez-Schael I, Salinas B, Tomat M, et al.

Publication date: 2007

Ending Preventable Child Deaths From Pneumonia and Diarrhoea by 2025 – The Integrated Global Action Plan for Pneumonia and Diarrhoea (GAPPD)

This report proposes a cohesive approach to ending preventable pneumonia and diarrhea deaths in children. It outlines a protect, prevent, and treat framework that integrates proven effective interventions for pneumonia and diarrhea, including the …

Author: World Health Organization, United Nations Children's Fund

Publication date: 2013

The Equity Impact Vaccines May Have on Averting Deaths and Medical Impoverishment in Developing Countries

This article, published in Health Affairs, reports on an analysis of how equitable the health and economic benefits of vaccines are across different countries. The authors estimated the differential health impact (measured as the number of deaths …

Author: Chang AY, Riumallo-Herl C, Perales NA, et al.

Publication date: 2018

Estimating Global, Regional and National Rotavirus Deaths in Children Aged <5 Years: Current Approaches, New Analyses and Proposed Improvements

This article, published in PLoS ONE, reports figures for global, regional, and national rotavirus-related deaths in children under five years of age, and discusses updated methodologies for data analysis. In order to reduce delays in …

Author: Clark A, Black R, Tate J, et al.

Publication date: 2017

Estimating the Full Public Health Value of Vaccination

This conference report, published in Vaccine, builds upon a discussion in the public health community on how to assess and incorporate, in addition to safety and measures of protective efficacy, the full public health value (FPHV) of preventive …

Author: Gessner BD, Kaslow D, Louis J, et al.

Publication date: 2017

Evaluaciónde Costo-Efectividad de la Vacuna Anti-rotavirus en Chile

This article, published in Revista Médica de Chile, outlines an economic model that determined rotavirus vaccination is a cost-effective intervention that can effectively reduce the disease burden and healthcare costs of rotavirus …

Author: Constenla D, O'Ryan M, Navarrete M, Antil L, Rheingans R

Publication date: 2006

Evaluating the Potential Risks and Benefits of Infant Rotavirus Vaccination in England

This article, published in Vaccine, reports on a risk-benefit analysis of rotavirus vaccination that compared potential vaccine-related risks with estimated vaccine benefits in the 2012 birth cohort in England. The authors estimate that rotavirus …

Author: Clark A, Jit M, Andrews N, Atchison C, Edmunds WJ, Sanderson C

Publication date: 2014

Evaluation of Cost-Effectiveness of Live Oral Pentavalent Reassortant Rotavirus Vaccine Introduction in Ghana

This article, published in Vaccine, estimates the cost-effectiveness of introducing the rotavirus vaccine RotaTeq® in Ghana. The authors estimated the average costs of treating children with diarrhea in the Ashanti region of Ghana as inpatients and …

Author: Abbott C, Tiede B, Armah G, Mahmoud A

Publication date: 2012

Evaluation of Vaccines Against Enteric Infections: A Clinical and Public Health Research Agenda for Developing Countries

This article, from the Philosophical Transactions of the Royal Society B, provides a review of the enteric vaccines currently available and their lack of use in developing countries. The author purports that the reasons for this are multiple and …

Author: Clemens J

Publication date: 2011

Expanding the Evidence Base to Inform Vaccine Introduction: Program Costing and Cost-Effectiveness Analyses

This supplement to Vaccine contains 38 articles featuring country-led research to support real-time policymaking, including cost-effectiveness, program costing, and analyses of financial flows for vaccine introduction. It highlights work undertaken …

Author: Andrus JK, Walker DG, eds.

Publication date: 2015

From Introduction to Impact: The Story of Rotavirus Vaccines

This video follows three countries—Nicaragua, Ghana, and Malawi—that helped pave the way for rotavirus vaccine introductions in low-income countries worldwide. Rotavirus vaccines are saving lives and improving health in countries where they …

Author: PATH

Publication date: 2017

Fulfilling the Promise of Rotavirus Vaccines: How Far Have We Come Since Licensure?

This review, published in The Lancet Infectious Diseases, summarizes the role of rotavirus vaccination in reducing childhood hospitalizations and deaths due to severe diarrhea. The authors also highlight insights revealed through routine …

Author: Patel MM, Glass R, Desai R, Tate JE, Parashar UD

Publication date: 2012

Gastroenteritis Hospitalizations in Older Children and Adults in the United States Before and After Implementation of Infant Rotavirus Vaccination

This article, published in the Journal of the American Medical Association, reports on a study that explored the indirect impact of rotavirus vaccines on older age groups. The authors assessed patterns of gastroenteritis hospitalizations among …

Author: Gastañaduy PA, Curns AT, Parashar UD, Lopman BA

Publication date: 2013

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