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Total results with these characteristics: 66

Topic: Vaccine stabilization and formulation

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Guidelines on the International Packaging and Shipping of Vaccines

This widely used reference from WHO has been updated according to new developments in vaccine stability, temperature monitoring, and recently pre-qualified vaccines.

Author: World Health Organization

Publication date: 2005

Heat-Stable Measles Vaccine Produced by Spray Drying

This article, published in Vaccine, reports on the development of a heat-stable measles vaccine powder using a combination of unique stabilizers and mild spray-drying process conditions. The researchers identified spray drying as the optimal …

Author: Ohtake S, Martin RA, Yee L, et al.

Publication date: 2010

Immunization Safety: A Global Priority

This entire issue of the Bulletin of the World Health Organization is devoted to the topic of immunization safety, including vaccine quality, adverse events reporting, and safety of immunization injections.

Author: World Health Organization

Publication date: 2000

Improving the Reach of Vaccines to Low-Resource Regions, With a Needle-Free Vaccine Delivery Device and Long-Term Thermostabilization

In this article, published in the Journal of Controlled Release, the authors describe how dry-coated microprojections, a needle-free vaccine delivery device, can deliver vaccine to abundant antigen-presenting cells in the skin and induce efficient …

Author: Chen X, Fernando GJP, Crichton ML, et al.

Publication date: 2011

Influenza Vaccine Effectiveness in the United States During the 2015–2016 Season

This article, published in The New England Journal of Medicine, reports the results of a study to examine the effectiveness of the live attenuated influenza vaccine (LAIV) and inactivated influenza vaccine (IIV) formulations used in the 2015–2016 …

Author: Jackson ML, Chung JR, Jackson LA, et al.

Publication date: 2017

Mucosal Immunization Technologies

PATH developed a mucosal immunization technology platform--viable in two formats--that builds on several proven formulation, adjuvant, and delivery technologies that enable the efficient sublingual administration of subunit vaccines. Part of PATH's …

Author: PATH

Publication date: 2013

Neither Antibody to a Group B Streptococcal Conjugate Vaccine nor the Vaccine Itself is Teratogenic in Rabbits

This article, published in Human Vaccines, describes a group B Streptococcus (GBS) type-III capsular polysaccharide (CPS)-tetanus toxoid vaccine lot manufactured under current Good Manufacturing Practice Guidelines. The authors also provide an …

Author: Paoletti LC, Guttormsen H-K, Christian MS, Hoberman AM, McInnes P

Publication date: 2008

Opportunities and Challenges of Developing Thermostable Vaccines

This article, published in Expert Review of Vaccines, reviews approaches being used to develop thermostable vaccine formulations that are resistant to damage caused by freezing or excessive heat and could reduce dependence on the cold …

Author: Chen D, Kristensen D

Publication date: 2009


The Op.ti.mize e-newsletter is a quarterly publication that highlights advances and innovations in health care logistics, technologies, and policy. Developed by Project Optimize, a collaboration between the World Health Organization and PATH, this …

Author: PATH, World Health Organization

Potency of Clinical Group B Streptococcal Conjugate Vaccines

This article, published in Vaccine, discusses the potency of clinical group B streptococcal (GBS) capsular polysaccharide-protein conjugate vaccines. It examines liquid versus lyophilized preparations, and the author suggests that lyophilization in …

Author: Paoletti LC

Publication date: 2001

Presentation Matters: Buffers, Packaging, and Delivery Devices for New, Oral Enteric Vaccines for Infants

This article, published in Human Vaccines & Immunotherapeutics, highlights the importance of final vaccine presentation features in achieving optimal vaccine impact for new oral enteric vaccine candidates. Oral administration of vaccines …

Author: Lal M, Jarrahian C

Publication date: 2017

Preventing Bacterial Infections With Pilus-Based Vaccines: The Group B Streptococcus Paradigm

This article, published in the Journal of Infectious Diseases, reports the results of a study that determined whether a vaccine containing a combination of proteins from three pilus types can provide broad protection against group B Streptococcus …

Author: Margarit I, Rinaudo CD, Galeotti CL, et al.

Publication date: 2009

Preventing Vaccine Freezing in the Cold Chain

Vaccine freezing in the cold chain is increasingly recognized as a serious threat to immunization programs. This zipped set of materials includes background information on the freezing problem (two literature reviews and a PowerPoint presentation); …

Author: PATH

Publication date: 2003

Protecting Aluminum-Adjuvanted Vaccines From Freeze Damage

This fact sheet describes how PATH developed a low-cost and straightforward technology for protecting aluminum-adjuvanted liquid vaccines from the irreversible damage that results from freezing. Many current vaccines of importance to global health …

Author: PATH

Publication date: 2012

Public Assessment Summary Report – Japanese Encephalitis Vaccine, Live (Human)

This document provides a summary of a live attenuated Japanese encephalitis vaccine, including information on the use of the vaccine, dosing, formulation, and safety and immunogenicity results from clinical trials.

Author: World Health Organization

Publication date: 2013

Pull Mechanisms for Value-Added Technologies for Vaccines

Project Optimize, a collaboration between PATH and the World Health Organization, commissioned this white paper to examine the issues influencing vaccine producer willingness to advance, adopt, and commercialize value-added technologies for …

Author: PATH, World Health Organization

Publication date: 2009

Recombinant Group B Streptococcus Beta C Protein and a Variant With the Deletion of its Immunoglobulin A-Binding Site Are Protective Mouse Maternal Vaccines and Effective Carriers in Conjugate Vaccines

This article, published in Infection and Immunity, reports the results of a study in mice that examined immunogenicity and protective efficacy of a recombinant group B Streptococcus beta C protein (rBCP), an rBCP modified to eliminate its …

Author: Yang H-H, Madoff LC, Guttormsen H-K, Liu Y-D, Paoletti LC

Publication date: 2007

Reconstitution Technologies

This fact sheet provides an overview of single-dose, prefilled reconstitution devices (SPRDs), which can make reconstitution of critical vaccines safer and more economical. SPRDs can help eliminate adverse events or wastage that can occur with …

Author: PATH

Publication date: 2013

Safety, Tolerability, and Immunogenicity of Pentavalent Rotavirus Vaccine Manufactured by a Modified Process

This article, published in the Pediatric Infectious Disease Journal, describes the results of a Phase 3 study of a modified formulation of RotaTeq® (RV5) rotavirus vaccine that was developed to be stable at 37°C for 7 days and that has an …

Author: Martinón-Torres F, Dionne M, Greenberg D, et al.

Publication date: 2017

Spray Drying and Vaccine Stabilization

Research on spray drying as a processing method to improve vaccine stabilization and to enable novel routes of vaccine delivery has produced promising results; however, the method has yet to be adopted for the manufacture of vaccine products by the …

Author: McAdams D, Chen D, Kristensen D

Publication date: 2012

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