Vaccines for Preventing Rotavirus Diarrhoea: Vaccines in Use
This review, published in the Cochrane Database of Systematic Reviews, evaluates three rotavirus vaccines currently in use: Rotarix and RotaTeq, which have been evaluated in several large trials and are approved for use in many countries; and Lanzhou Lamb Rotavirus vaccine (LLR), which is approved for use in China only. Data from this review show that Rotarix and RotaTeq are effective vaccines, and support the World Health Organization's recommendation to include rotavirus vaccination of infants into national immunization programs, especially in countries with a high burden of diarrheal deaths in children younger than five years of age. The authors recommend new trials with head-to-head comparisons of both vaccines. They also support trials comparing LLR with placebo, data generation for special groups of children such as preterm infants and malnourished children, and extensive monitoring of adverse events where the use of vaccines is routine. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)
Author: Soares-Weiser K, MacLehose H, Ben-Aharon I, Goldberg E, Pitan F, Cunliffe N
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Citation: Soares-Weiser K, MacLehose H, Ben-Aharon I, Goldberg E, Pitan F, Cunliffe N. Vaccines for Preventing Rotavirus Diarrhoea: Vaccines in Use. Cochrane Database of Systematic Reviews 2010;5.
Resource types: Peer-reviewed journal