Understanding Reduced Rotavirus Vaccine Efficacy in Low Socio-Economic Settings
Rotavirus vaccine efficacy ranges from more than 90 percent in high socio-economic settings (SES) to 50 percent in low SES. The authors of this article, published in PLOS ONE, developed a mathematical model to predict rotavirus vaccine efficacy in high, middle, and low SES based on data specific for each setting on incidence, protection conferred by natural infection, and immune response to vaccination. They then examined factors affecting efficacy. Vaccination was predicted to prevent 93, 86, and 51 percent of severe rotavirus gastroenteritis in high, middle, and low SES, respectively. Also predicted was that vaccines are most effective against severe disease and efficacy declines with age in low but not high SES. The authors determined that reduced immunogenicity of vaccination and reduced protection conferred by natural infection are the main factors that compromise efficacy in low SES.
Author: Lopman BA, Pitzer VE, Sarkar R, et al.
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Citation: Lopman BA, Pitzer VE, Sarkar R, et al. Understanding Reduced Rotavirus Vaccine Efficacy in Low Socio-Economic Settings. PLOS ONE. 2012;7(8):e41720.
Resource types: Peer-reviewed journal