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Global Manual on Surveillance of Adverse Events Following Immunization

Monitoring of adverse events following immunization (AEFI) is an essential strategy for ensuring the safety of vaccines. This manual provides guidance on improving the quality and efficiency of AEFI surveillance activities for managers of immunization programs, staff of national regulatory authorities, immunization service providers, staff of pharmacovigilance centers, and other stakeholders in immunization services. It shares information on the basic principles of immunization and vaccines and provides a clear understanding of the newer concepts of AEFI, establishing AEFI surveillance systems including the methodologies and tools of reporting, and investigating and performing causality assessment. For informed decision making, the manual outlines the process of making the best use of surveillance data and responding to crisis, including a communication strategy on immunization safety for the public and the media.

Author: World Health Organization

Published: 2014

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5.25 MB PDF (Located at

Resource types: Training material

Diseases/vaccines: Not disease/vaccine specific

Topics: Advocacy and communications, Introduction and service delivery, Vaccine safety and performance

Regions: Global