Immunogenicity and Reactogenicity of Alternative Schedules of HPV Vaccine in Vietnam: A Cluster Randomized Noninferiority Trial
A potential barrier to human papillomavirus (HPV) vaccine introduction in low-resource countries is the three-dose schedule over a six-month period of time. This article, published in the Journal of the American Medical Association, describes the results of a study comparing two alternative dosing schedules (at 0, 3, and 9 months and at 0, 6, and 12 months) for the HPV vaccine with the standard schedule (at 0, 2, and 6 months) in Vietnam. The results showed that the antibody concentrations from the two alternative dosing schedules were not inferior to those from the standard schedule.
Author: Neuzil KM, Canh DG, Thiem VD, et al.
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Citation: Neuzil KM, Canh DG, Thiem VD, et al. Immunogenicity and Reactogenicity of Alternative Schedules of HPV Vaccine in Vietnam: A Cluster Randomized Noninferiority Trial. Journal of the American Medical Association. 2011;305(14):1424-1431.
Resource types: Peer-reviewed journal
Diseases/vaccines: Human papillomavirus (HPV)