Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine
This article, published in The New England Journal of Medicine, reports on an analysis of samples from an efficacy study of the RTS,S/AS01 malaria vaccine to determine whether the vaccine efficacy was specific to certain parasite genotypes at the circumsporozoite protein locus. The results suggest that among children 5 to 17 months of age, the RTS,S vaccine has greater activity against malaria parasites with the matched circumsporozoite protein allele than against mismatched malaria. The authors conclude that overall vaccine efficacy in this age category will depend on the proportion of matched alleles in the local parasite population; in this trial, less than 10 percent of parasites had matched alleles, which likely contributed to the lower efficacy of the vaccine among this age group.
Author: Neafsey DE, Juraska M, Bedford T, et al.
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Citation: Neafsey DE, Juraska M, Bedford T, et al. Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine. The New England Journal of Medicine. 2015;Early Online Publication.
Resource types: Peer-reviewed journal