Maternal Transfer of RSV Immunity in Cotton Rats Vaccinated During Pregnancy
Maternal antibodies against respiratory syncytial virus (RSV) can protect infants from the disease, but the protection is short-lived and the methods for extending and augmenting protection are not known. This article, published in Vaccine, reports the results of a study that aimed to develop an animal model of maternal RSV vaccination. The authors found that vaccination and boosting the cotton rat mothers with RSV produced high levels of neutralizing antibody. They conclude that this model could be used to define vaccine preparations that could improve preexistent immunity and induce subsequent transfer of efficient immunity to infants.
Author: Blanco JCG, Pletneva LM, Oue RO, Patel MC, Boukhvalova MS
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Citation: Blanco JCG, Pletneva LM, Oue RO, Patel MC, Boukhvalova MS. Maternal Transfer of RSV Immunity in Cotton Rats Vaccinated During Pregnancy. Vaccine. 2015;33(41):5371-5379.
Resource types: Peer-reviewed journal
Diseases/vaccines: Respiratory syncytial virus (RSV)