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Typhoid Fever Vaccination Strategies

This article, published in Vaccine, reviews experiences with various vaccination strategies using the currently availabile typhoid vaccines—injectable Vi polysaccharide vaccine (ViPS), oral Ty21a vaccine, and injectable typhoid conjugate vaccine (TCV). Strategies that have been used in field research and program settings include preventive use for endemic control, reactive use for outbreak control, community-based routine vaccination, community-based campaigns, and school-based vaccination. The authors assessed the rationale, acceptability, effectiveness, impact, and implementation lessons of these strategies and found all strategies to be acceptable, feasible, and effective in the settings evaluated. The authors conclude that implementation lessons should be applied to design optimal vaccination strategies using TCVs, which have several anticipated advantages over the ViPS and Ty21a vaccines such as potential for use in infant immunization programs and longer duration of protection. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Date KA, Bentsi-Enchill A, Marks F, Fox K

Published: 2015

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Citation: Date KA, Bentsi-Enchill A, Marks F, Fox K. Typhoid Fever Vaccination Strategies. Vaccine. 2015;33(Suppl 3):C55-C61.

Resource types: Peer-reviewed journal

Diseases/vaccines: Typhoid

Topics: Introduction and service delivery, Disease/vaccine specific information

Regions: Global