Vaccines Against Seasonal and Pandemic Influenza and the Implications of Changes in Substrates for Virus Production
This article, published in Clincial Infectious Diseases, examines the challenges of producing influenza vaccines. Influenza virus changes contantly, which means vaccines must change to keep up—a complex collaboration between surveillance laboratories, regulatory agencies, and industry. The authors outline the perceived advantages and disadvantages to using a cell-based production process and conclude that that changing the virus growth substrate from chicken eggs to cells could have a profound effect on the influenza vaccine development process.
Author: Plotkin S, Minor PD
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Citation: Plotkin S, Minor PD. Vaccines Against Seasonal and Pandemic Influenza and the Implications of Changes in Substrates for Virus Production. Clinical Infectious Diseases. 2010;50(4):560-565.
Resource types: Peer-reviewed journal