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Total results with these characteristics: 98

Disease: Shigellosis and enterotoxigenic Escherichia coli (ETEC)

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The 2016 Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference

This special issue of Vaccine reports on the proceedings of PATH's inaugural VASE Conference, which brought together more than 250 experts in Washington, DC, in June 2016 to discuss topics related to Shigella and enterotoxigenic Escherichia coli …

Author: Walker RI, Oaks EV, eds.

Publication date: 2017

The 2018 Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference

This special issue of Vaccine reports on the proceedings of PATH's second international VASE Conference that took place in Mexico City, Mexico, in June 2018. Almost 200 experts representing 27 countries came together to discuss topics related to …

Author: Walker RI, Riddle MS, Clifford A, eds.

Publication date: 2019

Analysis of Strategies to Successfully Vaccinate Infants in Developing Countries Against Enterotoxigenic E. coli (ETEC) Disease

This article, published in Vaccine, outlines current candidates for a safe and effective vaccine against ETEC. The authors argue that a critical roadblock to achieving this goal has not been the science as much as the lack of a sufficiently funded …

Author: Walker RI, Steele D, Aguado T, Ad Hoc ETEC Technical Expert Committee

Publication date: 2007

An Assessment of Enterotoxigenic Escherichia coli and Shigella Vaccine Candidates for Infants and Children

This review article, published in Vaccine, describes the approaches to enterotoxigenic Escherichia coli (ETEC) and Shigella vaccines that are currently under development, including a range of both cellular and subunit approaches for each pathogen. …

Author: Walker RI

Publication date: 2015

Bacterial Diarrhea

This article, published in the New England Journal of Medicine, provides a description of bacterial diarrhea and evidence supporting various strategies to combat this problem. Also included are a list of pathogens that cause bacterial diarrhea and …

Author: DuPont HL

Publication date: 2009

Burden and Aetiology of Diarrhoeal Disease in Infants and Young Children in Developing Countries (the Global Enteric Multicenter Study, GEMS): A Prospective, Case-Control Study

This article, published in The Lancet, reports on results of the Global Enteric Multicenter Study (GEMS), which was designed to identify the aetiology and population-based burden of pediatric diarrheal disease in sub-Saharan Africa and south Asia. …

Author: Kotloff KL, Nataro JP, Blackwelder WC, et al.

Publication date: 2013

Burden of Enterotoxigenic Escherichia coli and Shigella Non-Fatal Diarrhoeal Infections in 79 Low-Income and Lower Middle-Income Countries: A Modelling Analysis

This article, published in the The Lancet Global Health, reports the results of a modelling study to estimate the effect of enterotoxigenic Escherichia coli (ETEC) and Shigella-related diarrhea on stunting and the associated mortality due to other …

Author: Anderson JD, Bagamian KH, Muhib F, et al.

Publication date: 2019

The Cascading Burden of Diarrheal Disease: Revealing the Hidden Costs of ETEC and Shigella Diarrhea

This interactive data visualization tool tells the full story behind the global burden of enterotoxigenic Escherichia coli and Shigella, the two leading bacterial causes of diarrhea. The visualization features a new set of global disease burden …

Author: PATH

Publication date: 2016

The Case for Investment in Enterotoxigenic Escherichia coli Vaccines

This market assessment aims to increase the awareness of biotechnology and pharmaceutical companies worldwide about the opportunities and potential markets that exist for low-cost and effective vaccines against enterotoxigenic Escherichia coli …

Author: PATH; BIO Ventures for Global Health

Publication date: 2011

Center for Vaccine Innovation and Access

This web page provides information about the work of PATH’s Center for Vaccine Innovation and Access, which brings together expertise across every stage of vaccine research, development, and introduction to make lifesaving vaccines globally …

Author: PATH

Characterization of Mucosal Immune Responses to Enterotoxigenic Escherichia coli Vaccine Antigens in a Human Challenge Model: Response Profiles After Primary Infection and Homologous Rechallenge With Strain H10407

There is currently a poor understanding of the immune responses that correlate best with protection against enterotoxigenic Escherichia coli (ETEC) illness, which presents a challenge to vaccine development efforts. This article, published in …

Author: Chakraborty S, Harro C, DeNearing B, et al.

Publication date: 2016

Clinical Trial to Evaluate Safety and Immunogenicity of an Oral Inactivated Enterotoxigenic Escherichia coli Prototype Vaccine Containing CFA/I Overexpressing Bacteria and Recombinantly Produced LTB/CTB Hybrid Protein

This article, published in Vaccine, describes the results of a randomized, comparator controlled, double-blind Phase 1 trial in 60 Swedish adults testing a prototype of a new oral vaccine candidate against enterotoxigenic Escherichia coli (ETEC) …

Author: Lundgren A, Leach S, Tobias J, et al.

Publication date: 2013

A Combination Vaccine Consisting of Three Live Attenuated Enterotoxigenic Escherichia coli Strains Expressing a Range of Colonization Factors and LTB is Well Tolerated and Immunogenic in a Placebo-Controlled Double-Blind Phase 1 Trial in Healthy Adults

This article, published in Clinical and Vaccine Immunology, describes the results of a Phase 1 trial of a trivalent, live attenuated enterotoxigenic Escherichia coli vaccine candidate, ACE527. The study indicated that ACE527 had a strong safety …

Author: Harro C, Sack D, Bourgeois AL, et al.

Publication date: 2011

Combination Vaccines Against Diarrheal Diseases

This article, published in Human Vaccines & Immunotherapeutics, outlines the need for the development of affordable and effective combination vaccines against diarrheal diseases. Despite the well-documented global burden of diarrheal diseases, …

Author: Venkatesan MM, Van de Verg LL

Publication date: 2015

Comparison of Cost-of-Illness with Willingness-to-Pay Estimates to Avoid Shigellosis: Evidence from China

Published in Health Policy and Planning, this compares cost-of-illness (COI) with stated preference estimates of willingness-to-pay associated with shigellosis in a rural area of China to evaluate the economic benefits of disease prevention. The …

Author: Guh S, Xingbao C, Poulos C, et al.

Publication date: 2008

Conservation and Immunogenicity of Novel Antigens in Diverse Isolates of Enterotoxigenic Escherichia coli

This article, published in PLoS Neglected Tropical Diseases, reports on a study that aimed to identify protective antigens shared by many enterotoxigenic Escherichia coli (ETEC) strains to help inform the development of new vaccine candidates. Using …

Author: Luo Q, Qadri F, Kansal R, Rasko DA, Sheikh A, Fleckenstein JM

Publication date: 2015

Considerations for Using ETEC and Shigella Disease Burden Estimates to Guide Vaccine Development Strategy

This article, published in Vaccine, summarizes various enterotoxigenic Escherichia coli (ETEC) and Shigella disease burden estimates, based on a review of current literature and informal consultations with leading stakeholders in enteric disease …

Author: Hosangadi D, Smith PG, Giersing BK

Publication date: 2017

Cross-Reactivity and Avidity of Antibody Responses Induced in Humans by the Oral Inactivated Multivalent Enterotoxigenic Escherichia coli (ETEC) Vaccine ETVAX

This article, published in Vaccine, reports on results of research conducted with samples collected during two Phase 1 trials of the oral inactivated, multivalent ETEC vaccine candidate ETVAX. ETVAX consists of four E. coli strains over-expressing …

Author: Leach S, Lundgren A, Carlin N, Löfstrand M, Svennerholm A-M

Publication date: 2017

Current Progress in Developing Subunit Vaccines Against Enterotoxigenic Escherichia coli-Associated Diarrhea

This article, published in Clinical and Vaccine Immunology, reports on the development status of subunit vaccines against enterotoxigenic Escherichia coli (ETEC). Currently, there are no available vaccines against ETEC-associated diarrhea. …

Author: Zhang W, Sack DA

Publication date: 2015

DefeatDD.org

This website provides comprehensive resources on diarrheal disease treatment interventions, including low-osmolarity oral rehydration solution, zinc treatment, and rotavirus vaccines. Traditional interventions such as improved sanitation and …

Author: PATH

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