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Comparison of Strategies and Incidence Thresholds for Vi Conjugate Vaccines Against Typhoid Fever: A Cost-Effectiveness Modeling Study

This article, published in the Journal of Infectious Diseases, reports the results of a study that aimed to identify the strategies and associated epidemiologic conditions under which typhoid Vi conjugate vaccines (TCVs) would be cost-effective. The authors developed an age-structured transmission and cost-effectiveness model that simulated multiple vaccination strategies with a TCV. They found that TCVs would be highly cost-effective in low-income countries in settings of moderate typhoid incidence. The results were sensitive to case-fatality rates, underscoring the need to consider factors contributing to typhoid mortality, such as healthcare access and drug-resistant typhoid, in the global vaccination strategy.

Author: Lo NC, Gupta R, Stanaway JD, et al.

Published: 2018

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(Located at academic.oup.com)

Citation: Lo NC, Gupta R, Stanaway JD, et al. Comparison of Strategies and Incidence Thresholds for Vi Conjugate Vaccines Against Typhoid Fever: A Cost-Effectiveness Modeling Study. Journal of Infectious Diseases. 2018;Early Online Publication.

Resource types: Peer-reviewed journal

Diseases/vaccines: Typhoid

Topics: Immunization financing, Disease/vaccine specific information

Regions: Global