This article, published in The Lancet, reports the results of an analysis examining the impact and effectiveness of human papillomavirus (HPV) vaccines in real-world settings. The results show substantial decreases in HPV infections and pre-cancerous cervical lesions following the implementation of three-dose HPV vaccination programs as well as evidence of herd effects among boys and older women. Additionally, programs with multi-cohort vaccination and high coverage had a greater direct impact and herd effects. The authors conclude that these results should be considered within the rapidly changing landscape of HPV vaccination, with several countries recently switching to two-dose schedules, gender-neutral vaccination, and the nonavalent vaccine, and with research examining one-dose HPV vaccination, two-dose vaccination in older populations, and cervical cancer elimination strategies. ABSTRACT ONLY. (Learn how users in developing countries can gain free access to journal articles.)

Author: Drolet M, Bénard E, Pérez N, Brisson M

Published: 2019

Resource types: Peer-reviewed journal

Diseases/vaccines: Human papillomavirus (HPV)

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Global