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Impact of the Introduction of Rotavirus Vaccine on Hospital Admissions for Diarrhea Among Children in Kenya: A Controlled Interrupted Time-Series Analysis

This article, published in Clinical Infectious Diseases, reports the results of a study to evaluate the vaccine impact on the incidence of rotavirus-associated hospitalizations following vaccine introduction. The results demonstrated a substantial reduction in rotavirus-associated hospitalizations and all-cause diarrhea following the introduction of rotavirus vaccine in Kenya. In the first year post-introduction, rotavirus-associated hospitalizations decreased by 57 percent and 59 percent in Kilifi and Siaya, respectively. In the second year, there was an 80 percent reduction in rotavirus-associated hospitalizations in Kilifi and 82 percent reduction in Siaya. These reductions were sustained at both sites into the third year.

Author: Otieno GP, Bottomley C, Khagayi S, et al.

Published: 2019

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(Located at academic.oup.com)

Citation: Otieno GP, Bottomley C, Khagayi S, et al. Impact of the Introduction of Rotavirus Vaccine on Hospital Admissions for Diarrhea Among Children in Kenya: A Controlled Interrupted Time-Series Analysis. Clinical Infectious Diseases. 2019;Early Online Publication.

Resource types: Peer-reviewed journal

Diseases/vaccines: Rotavirus

Topics: Vaccine safety and performance, Disease/vaccine specific information

Regions: Africa